Hieronim Jakubowski Selected Research

homocysteine thiolactone

10/2020	Proteomic exploration of cystathionine β-synthase deficiency: implications for the clinic.
7/2020	Quantification of homocysteine thiolactone in human saliva and urine by gas chromatography-mass spectrometry.
1/2019	Sex affects N-homocysteinylation at lysine residue 212 of albumin in mice.
5/2018	Paraoxonase 1 Q192R genotype and activity affect homocysteine thiolactone levels in humans.
1/2018	Mutations in Homocysteine Metabolism Genes Increase Keratin N-Homocysteinylation and Damage in Mice.
11/2016	N-Homocysteinylation impairs collagen cross-linking in cystathionine β-synthase-deficient mice: a novel mechanism of connective tissue abnormalities.
7/2015	Homocysteine thiolactone and N-homocysteinylated protein induce pro-atherogenic changes in gene expression in human vascular endothelial cells.
1/2014	Hyperhomocysteinemia and bleomycin hydrolase modulate the expression of mouse brain proteins involved in neurodegeneration.
1/2014	Inactivation of the paraoxonase 1 gene affects the expression of mouse brain proteins involved in neurodegeneration.
9/2012	Metabolism and neurotoxicity of homocysteine thiolactone in mice: protective role of bleomycin hydrolase.

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Hieronim Jakubowski Research Topics

Disease

22	Hyperhomocysteinemia 06/2019 - 11/2004
12	Cardiovascular Diseases (Cardiovascular Disease) 04/2022 - 11/2004
10	Atherosclerosis 07/2015 - 06/2004
7	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 01/2010
7	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019 - 01/2006
5	Stroke (Strokes) 10/2020 - 06/2004
5	Thrombosis (Thrombus) 01/2020 - 06/2006
4	Neural Tube Defects (Exencephaly) 04/2022 - 01/2006
4	Neoplasms (Cancer) 04/2022 - 10/2016
4	Homocystinuria 11/2020 - 11/2016
4	Inflammation (Inflammations) 04/2020 - 04/2011
4	Brain Diseases (Brain Disorder) 01/2019 - 06/2007
4	Malnutrition (Nutritional Deficiencies) 05/2018 - 01/2011
4	Inborn Genetic Diseases (Disease, Hereditary) 11/2016 - 06/2007
4	Vascular Diseases (Vascular Disease) 07/2015 - 01/2007
4	Coronary Artery Disease (Coronary Atherosclerosis) 07/2015 - 01/2005
4	Seizures (Absence Seizure) 01/2014 - 01/2012
3	Dementia (Dementias) 04/2022 - 10/2016
3	Cognitive Dysfunction 01/2021 - 01/2021
3	Obesity 04/2020 - 05/2016
3	Nutrition Disorders (Nutritional Disorders) 09/2012 - 06/2009
2	Atrophy 01/2021 - 01/2021
2	Tics (Tic) 01/2021 - 01/2021
2	Acute-Phase Reaction 01/2021 - 01/2020
2	Thromboembolism 10/2020 - 06/2019
2	Insulin Resistance 12/2015 - 09/2014
2	Kidney Diseases (Kidney Disease) 11/2014 - 08/2014
2	Hypertension (High Blood Pressure) 09/2014 - 01/2012
2	Fatty Liver 06/2014 - 01/2014
2	Myocardial Infarction 04/2011 - 09/2006
1	Parkinson Disease (Parkinson's Disease) 05/2022
1	COVID-19 04/2022
1	Atopic Dermatitis (Atopic Eczema) 01/2020
1	Ischemic Stroke 06/2019
1	Colorectal Neoplasms (Colorectal Cancer) 01/2019
1	Starvation 10/2016
1	Anemia 10/2016
1	Heart Diseases (Heart Disease) 07/2015

Drug/Important Bio-Agent (IBA)

38	HomocysteineIBA 01/2021 - 11/2004
31	Proteins (Proteins, Gene)FDA Link 01/2021 - 06/2004
28	homocysteine thiolactoneIBA 10/2020 - 02/2005
8	AntioxidantsIBA 01/2021 - 01/2012
8	Methionine (L-Methionine)FDA Link 01/2018 - 06/2007
6	Folic Acid (Vitamin M)FDA LinkGeneric 01/2019 - 06/2006
5	AutoantibodiesIBA 01/2021 - 06/2004
5	IronIBA 01/2021 - 01/2014
5	CystathionineIBA 10/2020 - 11/2010
5	Lysine (L-Lysine)FDA Link 01/2019 - 09/2008
4	Lipoproteins (Lipoprotein)IBA 01/2021 - 01/2014
4	Aryldialkylphosphatase (Paraoxonase)IBA 01/2021 - 02/2010
4	bleomycin hydrolaseIBA 08/2014 - 01/2010
3	CarbonIBA 04/2022 - 05/2018
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 06/2006
3	Vitamin B Complex (B Vitamins)IBA 01/2021 - 01/2021
3	EnzymesIBA 01/2021 - 01/2010
3	ProteomeIBA 01/2020 - 06/2014
3	Biological ProductsIBA 06/2019 - 07/2015
3	Amino Acids FDA Link 07/2015 - 01/2006
2	CopperIBA 01/2021 - 01/2018
2	HDL LipoproteinsIBA 01/2021 - 11/2014
2	Complement System Proteins (Complement)IBA 01/2021 - 01/2020
2	HydrolasesIBA 01/2021 - 11/2014
2	Triglycerides (Triacylglycerol)IBA 01/2021 - 09/2014
2	CollagenIBA 10/2020 - 11/2016
2	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2019 - 10/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 06/2014 - 01/2014
2	Glutathione (Reduced Glutathione)IBA 04/2011 - 11/2004
2	Sulfhydryl Compounds (Thiols)IBA 01/2010 - 11/2004
2	Methylenetetrahydrofolate Reductase (NADPH2) (Methylenetetrahydrofolate Reductase)IBA 06/2009 - 06/2007
2	Cystathionine beta-Synthase (Serine Sulfhydrase)IBA 06/2009 - 06/2007
2	AntibodiesIBA 09/2006 - 02/2005
1	RotenoneIBA 05/2022
1	Neuroprotective AgentsIBA 05/2022
1	SulfurIBA 04/2022
1	AluminumIBA 01/2021
1	Brain-Derived Neurotrophic Factor (BDNF)IBA 01/2021
1	phenylacetic acid (phenylacetate)FDA Link 01/2021
1	purineIBA 01/2021
1	SiliconIBA 01/2021
1	Fatty Acids (Saturated Fatty Acids)IBA 01/2021
1	Mitochondrial DNA (mtDNA)IBA 11/2020
1	Sulfur Amino AcidsIBA 10/2020
1	LipidsIBA 04/2020
1	Filaggrin ProteinsIBA 01/2020
1	Blood Proteins (Serum Proteins)IBA 06/2019
1	Biomarkers (Surrogate Marker)IBA 06/2018
1	Keratins (Keratin)IBA 01/2018
1	pyridinolineIBA 11/2016
1	ElementsIBA 10/2016
1	ThymineIBA 10/2016
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2015
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 12/2015
1	Arginine (L-Arginine)FDA Link 12/2015
1	MineralsIBA 09/2014
1	Gluconates (Copper Gluconate)IBA 09/2014
1	ZincIBA 09/2014
1	Indapamide FDA LinkGeneric 09/2014
1	Antihypertensive Agents (Antihypertensives)IBA 09/2014
1	CarbohydratesIBA 08/2014

Therapy/Procedure

1	Therapeutics 05/2016